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Dr. Matt Kaeberlein is an internationally acknowledged professional on the biology of aging and repeating on The Drive. In this episode, Matt discusses his research study findings on nutrition as it associates with aging and durability, consisting of the arise from his current evaluation short article in Science. From there, he and Peter dive deep into the literature on calorie limitation (CR), discussing the subtlety, advantages for life-span and healthspan, and possible drawbacks of CR. He goes over the epigenetic modifications that accompany age and prospective advantages and disadvantages of epigenetic reprogramming, typically considered as a remedy for reversing aging. Matt likewise discusses the effect of dietary protein on aging, consisting of the intriguing dichotomy around how protein, an important macronutrient, and rapamycin, a geroprotective particle, have opposite impacts on mTOR. In addition, he speaks about low-protein vs. high-protein diet plans and their results on muscle mass and death, in addition to the effect of IGF-1 signaling and development hormonal agent on life-span.
We talk about:
0: 00: 00 – Intro
0: 00: 08 – Challenges with comprehending the impacts of nutrition and studying interventions for aging
0: 05: 26 – How Peter’s and Matt’s convictions on nutrition and ideas optimum health have actually developed
0: 14: 48 – Calorie limitation for enhancing life-span in animal designs
0: 21: 05 – Utility of epigenetic clocks and possibility of epigenetic reprogramming
0: 32: 09 – Mutations and modifications to the epigenome with aging
0: 36: 21 – Epigenetic reprogramming: prospective advantages and disadvantages and whether it can operate in every organ/tissue
0: 44: 43 – First possible applications of anti-aging treatments and ideas for aging well
0: 49: 40 – Impact of calorie constraint on the body immune system, muscle mass, and strength
0: 59: 34 – Insights from well-known calorie limitation research studies in rhesus macaques
1: 09: 18 – An evolutionary point of view of the human diet plan
1: 19: 10 – Antiaging diet plans: Separating reality from fiction– Matt’s 2021 evaluation in Science
1: 27: 39 – Mouse designs of time-restricted feeding in the context of calorie limitation
1: 36: 38 – Nutritional interventions that regularly effect life expectancy in mice, and issues around effectiveness in people
1: 41: 46 – Differing effect of calorie constraint when begun later on in life
1: 49: 02 – Lifespan extension with rapamycin in older mice
1: 55: 38 – Relationship in between protein consumption and aging, and mouse research studies revealing protein constraint can extend life expectancy
2: 04: 07 – Impact of protein consumption on mTOR, and why inhibition of mTOR does not trigger muscle loss
2: 09: 37 – Low-protein vs. high-protein diet plans and their results on muscle mass, death, and more
2: 22: 16 – The effect of IGF-1 signaling and development hormonal agent on life expectancy
2: 37: 23 – Parting ideas on the contribution of nutrition to healthspan and life-span
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast concentrating on taking full advantage of health, durability, important thinking … and a couple of other things. With over 45 million episodes downloaded, it includes subjects consisting of fasting, ketosis, Alzheimer’s illness, cancer, psychological health, and far more.
Peter is a doctor concentrating on the used science of durability. His practice offers thoroughly with dietary interventions, workout physiology, sleep physiology, psychological and psychological health, and pharmacology to increase life-span (hold-up the start of persistent illness), while at the same time enhancing healthspan (lifestyle).
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