Click here for a records of this video: https://www.oncotarget.net/2022/07/11/ behind-the-study-molecular-characterization-of-lung-carcinomas-expressing-kk-lc-1/
Dr. Robert Hsu from the Department of Internal Medicine, Division of Medical Oncology, Norris Comprehensive Cancer Center and Hospital, University of Southern California, explains a current term paper he co-authored that was released by Oncotarget, entitled, “Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) revealing cancers.”
DOI – https://doi.org/1018632/ oncotarget.28132
Correspondence to – Jorge J. Nieva – jorge.nieva@med.usc.edu
Video records: https://www.oncotarget.net/2022/07/11/ behind-the-study-molecular-characterization-of-lung-carcinomas-expressing-kk-lc-1/
Abstract
Cancer/testis antigens (CTAs) are highly revealed in some strong growths however minimally revealed in regular tissue, making them enticing healing targets. KK-LC-1 (CXorf61) has cytoplasmic expression in stomach, breast, and lung cancer. We defined the molecular subtypes of non-small cell lung cancer (NSCLC) revealing KK-LC-1 to notify logical medical trials of T-cell receptor treatment (TCR-T) targeting KK-LC-1. 9790 NSCLC growths that went through entire transcriptome sequencing (Illumina NovaSeq) and NextGen DNA sequencing (NextSeq, 592 Genes and NovaSEQ, WES) at Caris Life Sciences (Phoenix, AZ) were examined. Growths were divided into quartiles based upon KK-LC-1 expression and pathological and molecular distinctions were examined. Adenocarcinoma had considerably greater KK-LC-1 expression than squamous cell cancer (typical, 3.25 vs. 1.17 records per million (TPM), p 0.0001). Growths with the greatest quartile of KK-LC-1 expression had a higher percentage of growths with high growth anomaly problem (TMB) (≥10 anomalies per megabase; 44% vs. 28% in Q1, p 0.001). Increased KK-LC-1 expression was related to increased M1 macrophage abundance. Greater levels of KK-LC-1 expression were seen in pan-wild type and KRAS altered growths and related to high TMB. TCR-T treatment directed versus KK-LC-1 needs to be thought about in clients whose scientific functions show these qualities.
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